Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1027	cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	mimic bacterial and viral DNA and was also shown to be involved in GVHD	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	graft-versus-host disease (GVHD)	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1027	cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	mimic bacterial and viral DNA and was also shown to be involved in GVHD	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	graft-versus-host disease (GVHD)	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1029	DNA (immune complexes) Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1029	DNA (immune complexes) Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1030	DNA (immune complexes Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1030	DNA (immune complexes Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1031	DNA (viral) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1031	DNA (viral) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1032	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	TRIF via a C-terminal RHIM domain interaction with RIP1 or RIP3	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem Assay
PRRID_1032	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	TRIF via a C-terminal RHIM domain interaction with RIP1 or RIP3	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem Assay
PRRID_1033	dsRNA Click for more detail	viral or cellular origin (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem Assay
PRRID_1033	dsRNA Click for more detail	viral or cellular origin (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem Assay
PRRID_1034	DNA (viral) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1034	DNA (viral) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1035	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem Assay
PRRID_1035	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem Assay
PRRID_1038	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1038	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1046	cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	mimic bacterial and viral DNA and was also shown to be involved in GVHD	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1046	cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	mimic bacterial and viral DNA and was also shown to be involved in GVHD	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1108	mRNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1108	mRNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1111	nonmethylated CpG-containing DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1111	nonmethylated CpG-containing DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1122	mRNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1122	mRNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1123	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1123	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1124	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NF-	24098508	2013	Pubchem_assay
PRRID_1124	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NF-	24098508	2013	Pubchem_assay
PRRID_1127	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1127	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1139	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor (TLR7) and Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	NA	NA	NA	important role in the immune response to viral infection	RT-PCR, Quantitative real-time PCR	23998272	2013	NA
PRRID_1139	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor (TLR7) and Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	NA	NA	NA	important role in the immune response to viral infection	RT-PCR, Quantitative real-time PCR	23998272	2013	NA
PRRID_1141	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1141	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1142	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1142	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1143	single-stranded RNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Synthetic	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1143	single-stranded RNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Synthetic	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1144	single-stranded RNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Synthetic	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1144	single-stranded RNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Synthetic	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1145	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1145	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1146	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1146	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1147	single-stranded RNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1147	single-stranded RNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1149	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	graft-versus-host disease (GVHD)	NA	NA	NA	NA	induces anti-viral response	NA	23985302	2013	NA
PRRID_1149	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	graft-versus-host disease (GVHD)	NA	NA	NA	NA	induces anti-viral response	NA	23985302	2013	NA
PRRID_1150	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	NA	NA	NA	important role in the immune response to viral infection	NF-	24098508	2013	NA
PRRID_1150	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	NA	NA	NA	important role in the immune response to viral infection	NF-	24098508	2013	NA
PRRID_1151	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NF-	24098508	2013	Pubchem_assay
PRRID_1151	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NF-	24098508	2013	Pubchem_assay
PRRID_1152	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	CgToll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	C. gigas	HEK293 cells	NA	NA	NA	NA	NA	NF-	24098508	2013	NA
PRRID_1152	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	CgToll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	C. gigas	HEK293 cells	NA	NA	NA	NA	NA	NF-	24098508	2013	NA
PRRID_1155	single-stranded RNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1155	single-stranded RNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1163	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	Toll/IL-1R (TIR) domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem_assay
PRRID_1163	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	Toll/IL-1R (TIR) domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem_assay
PRRID_1165	Unmethylated CpG DNA Click for more detail	Host/microbial (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1165	Unmethylated CpG DNA Click for more detail	Host/microbial (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1169	Unmethylated CpG DNA Click for more detail	Host/microbial (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1169	Unmethylated CpG DNA Click for more detail	Host/microbial (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1172	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR97.fasta	Q9NR97	1041	induces anti-viral response	NA	23985302	2013	Pubchem_assay
PRRID_1172	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR97.fasta	Q9NR97	1041	induces anti-viral response	NA	23985302	2013	Pubchem_assay
PRRID_1174	(LPS + CpG) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Nucleic Acid	Synthetic	both combinely accelerate lupus progression in anti-dsDNA antibody transgenic mice	NA	NA	C57BL/6 inbred mice	Splenocytes	NA	NA	NA	NA	NA	ELISA	24719374	2014	NA
PRRID_1174	(LPS + CpG) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Nucleic Acid	Synthetic	both combinely accelerate lupus progression in anti-dsDNA antibody transgenic mice	NA	NA	C57BL/6 inbred mice	Splenocytes	NA	NA	NA	NA	NA	ELISA	24719374	2014	NA
PRRID_1176	5‚Ä- triphosphate ssRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	RIG-1	Rig-like receptor (RLR)	Human	most adult tissues	helicase domain	O95786.fasta	O95786	925	mediate the efficient induction of the type I IFN response.	NA	24762827	2014	Pubchem_assay
PRRID_1176	5‚Ä- triphosphate ssRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	RIG-1	Rig-like receptor (RLR)	Human	most adult tissues	helicase domain	O95786.fasta	O95786	925	mediate the efficient induction of the type I IFN response.	NA	24762827	2014	Pubchem_assay
PRRID_1177	6-amino-9-benzyl-2- 106 (2-methoxyethoxy)-9H-purin-8-ol (SM360320) Click for more detail	NA	NC1=C2C(N(CC3=CC=CC=C3)C(O)=N2)=NC(OCCOC)=N1	NA	Nucleic Acid	Synthetic	stimulates TLR7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	pDCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1177	6-amino-9-benzyl-2- 106 (2-methoxyethoxy)-9H-purin-8-ol (SM360320) Click for more detail	NA	NC1=C2C(N(CC3=CC=CC=C3)C(O)=N2)=NC(OCCOC)=N1	NA	Nucleic Acid	Synthetic	stimulates TLR7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	pDCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1178	9-benzyl- 105 8-hydroxy-2-(2-methoxyethoxy)adenine Click for more detail	NA	COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3	NA	Nucleic Acid	Synthetic	stimulates TLR7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	pDCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1178	9-benzyl- 105 8-hydroxy-2-(2-methoxyethoxy)adenine Click for more detail	NA	COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3	NA	Nucleic Acid	Synthetic	stimulates TLR7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	pDCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1183	bacterial and viral nucleic acids containing CpG motifs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	HSP90	Pattern recognition receptor (PRR)	Human	induces pro-inflammatory cytokine response	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1183	bacterial and viral nucleic acids containing CpG motifs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	HSP90	Pattern recognition receptor (PRR)	Human	induces pro-inflammatory cytokine response	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1184	bacterial RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1184	bacterial RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1185	Viral RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1185	Viral RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1186	bacterialRNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor protein 12(NLRP12)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1186	bacterialRNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor protein 12(NLRP12)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1200	Viral RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	JNKBP1	Pattern recognition receptor (PRR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1200	Viral RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	JNKBP1	Pattern recognition receptor (PRR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1208	CL097 Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces the activation of NF-Œ∫B	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1208	CL097 Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces the activation of NF-Œ∫B	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1209	CL097 Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces the activation of NF-Œ∫B	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1209	CL097 Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces the activation of NF-Œ∫B	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1210	class B CpG DNA motifs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 21 (TLR2)	Toll-like receptor (TLR)	Chicken	Macrophages	Cell Compartment/Intracellular (ER compartment)	H9BPA7.fasta	H9BPA7	972	TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response	ELISA	24797893	2014	Pubchem_assay
PRRID_1210	class B CpG DNA motifs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 21 (TLR2)	Toll-like receptor (TLR)	Chicken	Macrophages	Cell Compartment/Intracellular (ER compartment)	H9BPA7.fasta	H9BPA7	972	TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response	ELISA	24797893	2014	Pubchem_assay
PRRID_1211	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1211	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1212	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1212	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1214	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1214	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1215	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1215	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1216	CpG ODN1826 Click for more detail	Bacteria	5‚Äô-tccatgacgttcctgacgtt-3‚Äô	20	Nucleic Acid	Synthetic	plays either stimulatory or protective roles in different murine lupus models	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 inbred mice	Splenocytes	intracellular	Q9NR96.fasta	Q9NR96	1032	endosomal TLR9 is crucial to promote the lupus progression.	ELISA	24719374	2014	Pubchem_assay
PRRID_1216	CpG ODN1826 Click for more detail	Bacteria	5‚Äô-tccatgacgttcctgacgtt-3‚Äô	20	Nucleic Acid	Synthetic	plays either stimulatory or protective roles in different murine lupus models	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 inbred mice	Splenocytes	intracellular	Q9NR96.fasta	Q9NR96	1032	endosomal TLR9 is crucial to promote the lupus progression.	ELISA	24719374	2014	Pubchem_assay

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